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Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Author(s):
Roshan Cools
,
Mark D'Esposito
Publication date
Created:
June 2011
Publication date
(Print):
June 2011
Journal:
Biological Psychiatry
Publisher:
Elsevier BV
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PMC
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Abstract
Brain dopamine (DA) has long been implicated in cognitive control processes, including working memory. However, the precise role of DA in cognition is not well-understood, partly because there is large variability in the response to dopaminergic drugs both across different behaviors and across different individuals. We review evidence from a series of studies with experimental animals, healthy humans, and patients with Parkinson's disease, which highlight two important factors that contribute to this large variability. First, the existence of an optimum DA level for cognitive function implicates the need to take into account baseline levels of DA when isolating the effects of DA. Second, cognitive control is a multifactorial phenomenon, requiring a dynamic balance between cognitive stability and cognitive flexibility. These distinct components might implicate the prefrontal cortex and the striatum, respectively. Manipulating DA will thus have paradoxical consequences for distinct cognitive control processes, depending on distinct basal or optimal levels of DA in different brain regions. Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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Embodied Memory
Author and article information
Journal
Title:
Biological Psychiatry
Abbreviated Title:
Biological Psychiatry
Publisher:
Elsevier BV
ISSN (Print):
00063223
Publication date Created:
June 2011
Publication date (Print):
June 2011
Volume
: 69
Issue
: 12
Pages
: e113-e125
Article
DOI:
10.1016/j.biopsych.2011.03.028
PMC ID:
3111448
PubMed ID:
21531388
SO-VID:
00606d3d-3e09-49ea-9b63-9adb2101e28b
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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