Therapeutic Interventions to Reduce Rates of Hospitalization and Death in Patients with Heart Failure: New Clinical Evidence

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Abstract

The high prevalence and poor prognosis of heart failure are a major concern. Hospitalization for heart failure accounts for a major proportion of health-care expenditure. A number of large clinical trials have been initiated to assess therapeutic strategies to improve prognosis for patients with this condition. Results from one of the largest and most recently completed of such studies, the Studies of Left Ventricular Dysfunction (SOLVD) trial, demonstrate that addition of the long-acting angiotensin-converting enzyme (ACE) inhibitor, enalapril to conventional therapy with diuretics and digoxin is associated with reduced rates of mortality and hospitalization for heart failure. Activation of the renin-angiotensin-aldosterone system (RAAS) appears to play an important role in the pathogenesis of this condition. The effects of treatment with this ACE inhibitor may be related to the degree of RAAS suppression it affords.

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 14 November 2008

Volume: 81

Issue: 1

Pages: 1-7

Affiliations

Department of Cardiac Medicine, National Heart and Lung Institute, London, UK

Article

Publisher ID: 175769 Other ID: Cardiology 1992;81:1–7

DOI: 10.1159/000175769

PubMed ID: 1477852

SO-VID: 0071b1ce-b1e8-42c6-be55-3ce7bc03ae52

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 22 June 1992

Date accepted : 26 June 1992

Page count

Pages: 7

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