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      Tumores malignos de las glándulas salivales: estudio retrospectivo de los pacientes tratados en el Hospital La Paz entre 2008 y 2018 Translated title: Malignant salivary gland tumors: a retrospective study of patients treated at La Paz hospital between 2008 and 2018

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          Abstract

          RESUMEN Introducción: Los tumores malignos de glándulas salivares son neoplasias malignas poco frecuentes, con una mayor incidencia en la glándula parótida. A pesar de su baja incidencia, las posibles complicaciones derivadas de los mismos pueden conllevar gran comorbilidad en los pacientes. Material y métodos: Hemos realizado un estudio retrospectivo, observacional y descriptivo de 105 pacientes con diagnóstico de neoplasias malignas de glándulas salivales en el Hospital Universitario La Paz. 102 corresponden a tumores primarios y 3 de ellos son metástasis de origen pulmonar. Resultados: En nuestra serie la glándula parótida es el lugar de asiento más frecuente. Histológicamente, el carcinoma adenoide quístico es el tumor más común. El 75,23 % de los pacientes fueron diagnosticados con una citología mediante punción y aspiración con aguja fina (PAAF), y los restantes casos con una biopsia. El tratamiento más indicado fue la cirugía, sobre todo para aquellos tumores de estirpe epitelial. Un 33,5 % recibió tratamiento adyuvante. Un 18 % de los pacientes que sufrieron complicaciones postquirúrgicas presentó parálisis facial. Durante el desarrollo de la enfermedad, el 23,80 % del total desarrolló metástasis a distancia, siendo el pulmón el órgano más afectado. El 26,66 % de los pacientes sufrió al menos una recidiva. La supervivencia a los 2 años fue del 87,7 % y a los 5 años del 75,5 %. Discusión: A diferencia de otros estudios, en nuestro caso la estirpe más frecuente es el carcinoma adenoide quístico, lo cual podría explicarse porque se trata de un hospital de referencia para el tratamiento de la parálisis facial. Uno de los puntos más importantes en el manejo de estos pacientes es, no solo el control locorregional y a distancia, sino también el tratamiento de las posibles secuelas.

          Translated abstract

          ABSTRACT Introduction: Salivary gland tumors are rare malignant neoplasms, with a higher incidence in the parotid gland. Despite their low incidence, the possible complications derived from them can lead to high comorbidity in patients. Methods: We conducted a retrospective, observational and descriptive study of 105 patients diagnosed with malignant neoplasms of the salivary glands at the Hospital Universitario La Paz. 102 correspond to primary tumors and 3 of them are metastases of pulmonary origin. Results: In our series the parotid gland is the most frequent site. Histologically, adenoid cystic carcinoma is the most common tumor. The 75.23 % of the patients were diagnosed with cytology by fine needle aspiration and puncture (FNA), and the remaining cases with biopsy. The most indicated treatment was surgery, especially for tumors of epithelial lineage. Some 33.5 % received adjuvant treatment. Some 18 % of the patients who suffered post-surgical complications presented facial paralysis. During the course of the disease, 23.80 % of the total developed distant metastases, the lung being the most affected organ. Of the patients, 26.66 % suffered at least one recurrence. Survival at 2 years was 87.6 % and at 5 years 75.3 %. Discussion: Unlike other studies, in our case the most frequent lineage of salivary glands tumors is adenoid cystic carcinoma. This could be explained because our hospital is a reference in facial paralysis. One of the most important points in the management of these patients is not only the local and distant control of the tumor, but also the treatment of possible sequelae.

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          A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions.

          The clinical usefulness of fine-needle aspiration cytology (FNAC) for the diagnosis of parotid gland lesions is controversial. Many accuracy studies have been published, but the literature has not been adequately summarized. We identified 64 studies on the diagnosis of malignancy (6,169 cases) and 7 studies on the diagnosis of neoplasia (795 cases). The diagnosis of neoplasia (area under the summary receiver operating characteristic [AUSROC] curve, 0.99; 95% confidence interval [CI], 0.97-1.00) had higher accuracy than the diagnosis of malignancy (AUSROC, 0.96; 95% CI, 0.94-0.97). Several sources of bias were identified that could affect study estimates. Studies on the diagnosis of malignancy showed significant heterogeneity (P < .001). The subgroups of American, French, and Turkish studies showed greater homogeneity, but the accuracy of these subgroups was not significantly different from that of the remaining subgroup. It is not possible to provide a general guideline on the clinical usefulness of FNAC for parotid gland lesions owing to the variability in study results. There is a need to improve the quality of reporting and to improve study designs to remove or assess the impact of bias.
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            Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases.

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              Cetuximab in recurrent and/or metastatic salivary gland carcinomas: A phase II study.

              EGFR overexpression in salivary gland carcinomas provides the rational for the investigation of anti-EGFR treatments in recurrent and/or metastatic salivary gland cancers (RMSGCs). The activity of cetuximab in terms of clinical benefit rate (CBR) defined as the occurrence of objective response (CR or PR) or stable disease (SD) for >or=6months was investigated. From April to December 2005, 30 patients [23 adenoid cystic carcinoma (ACC) and 7 non-ACC] were treated with cetuximab at 400mg/m(2)/week followed by 250mg/m(2)/week until progression, major toxicity or voluntary discontinuation. EGFR expression and gene status were retrospectively analyzed by immunocytochemistry and fluorescence in situ hybridization, respectively. A median of 14 courses of cetuximab (range 5-54) were infused. Skin toxicity was the main adverse event. Cetuximab provides a CBR in 50% (95% CL, 31 to 69%) of cases. None tumor sample showed EGFR gene amplification and an increased EGFR copy number was observed in 12% of samples, all ACC. Skin rash >or=G2, EGFR overexpression and EGFR copy number were not statistically correlated to CB. In RMSGCs further evaluations of EGFR targeting agents are advisable and should take place by appropriate tumor biological selection, differentiating ACC from non-ACC.
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                Author and article information

                Journal
                maxi
                Revista Española de Cirugía Oral y Maxilofacial
                Rev Esp Cirug Oral y Maxilofac
                Sociedad Española de Cirugía Oral y Maxilofacial y de Cabeza y Cuello (Madrid, Madrid, Spain )
                1130-0558
                2173-9161
                September 2021
                : 43
                : 3
                : 90-95
                Affiliations
                [1] Madrid orgnameHospital Universitario La Paz orgdiv1Servicio de Cirugía Oral y Maxilofacial España
                [2] Madrid orgnameHospital Universitario La Paz orgdiv1Servicio de Anatomía Patológica España
                [3] Barcelona orgnameHospital San Juan de Dios orgdiv1Servicio de Cirugía Oral y Maxilofacial España
                Article
                S1130-05582021000300090 S1130-0558(21)04300300090
                10.20986/recom.2021.1291/2021
                008ec498-f9cb-4a72-b6ca-70303fbb7baf

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 20 September 2021
                : 26 May 2021
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 12, Pages: 6
                Product

                SciELO Spain

                Categories
                Originales

                cabeza y cuello,Glándulas salivales,malignant tumors,head and neck,Salivary glands,tumores malignos

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