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      Host-gut microbiota metabolic interactions.

      Science (New York, N.Y.)

      Aging, Animals, Bacteria, metabolism, Diet, Gastrointestinal Tract, microbiology, Health, Humans, Immune System, physiology, Inflammation, Liver, Metabolic Diseases, Metabolic Networks and Pathways, Metagenome, Signal Transduction

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          Abstract

          The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.

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          Journal
          22674330
          10.1126/science.1223813

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