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      Rivaroxaban and dabigatran for suppression of mechanical heart valve-induced thrombin generation

      , , , ,
      The Annals of Thoracic Surgery
      Elsevier BV

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          Abstract

          Patients with mechanical heart valves (MHVs) require warfarin to prevent thromboembolism. Dabigatran was less effective than warfarin in patients with MHVs, which prompted a black box warning against the use of direct oral anticoagulants for this indication. However, rivaroxaban and apixaban, which inhibit factor Xa, have not been evaluated in patients with MHVs. To determine whether rivaroxaban and apixaban would be effective, we used MHV-induced thrombin generation assays to compare them with warfarin either alone or in combination with dabigatran.

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          Author and article information

          Journal
          The Annals of Thoracic Surgery
          The Annals of Thoracic Surgery
          Elsevier BV
          00034975
          December 2019
          December 2019
          Article
          10.1016/j.athoracsur.2019.10.091
          31877292
          009e2724-777b-4b3b-85f1-c40f2f1bef9d
          © 2019

          https://www.elsevier.com/tdm/userlicense/1.0/

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