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      Growth hormone deficiency and cerebral palsy

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          Abstract

          Cerebral palsy (CP) is a catastrophic acquired disease, occurring during development of the fetal or infant brain. It mainly affects the motor control centres of the developing brain, but can also affect cognitive functions, and is usually accompanied by a cohort of symptoms including lack of communication, epilepsy, and alterations in behavior. Most children with cerebral palsy exhibit a short stature, progressively declining from birth to puberty. We tested here whether this lack of normal growth might be due to an impaired or deficient growth hormone (GH) secretion. Our study sample comprised 46 CP children, of which 28 were male and 18 were female, aged between 3 and 11 years. Data obtained show that 70% of these children lack normal GH secretion. We conclude that GH replacement therapy should be implemented early for CP children, not only to allow them to achieve a normal height, but also because of the known neurotrophic effects of the hormone, perhaps allowing for the correction of some of the common disabilities experienced by CP children.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2010
          2010
          7 September 2010
          : 6
          : 413-418
          Affiliations
          [1 ]Department of Physiology, School of Medicine of Santiago de Compostela, Spain;
          [2 ]Medical Center Proyecto Foltra, 15886 Teo, Spain
          Author notes
          Correspondence: Jesús Devesa, Medical Center Proyecto Foltra, Cacheiras 64, 15886 Teo, Spain, Tel +34 981802928, Fax +34 981802928, Email jesus.devesa@ 123456usc.es
          Article
          tcrm-6-413
          2940749
          20856687
          © 2010 Devesa et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Original Research

          Medicine

          igf-i, growth hormone, cerebral palsy, short stature

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