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      Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

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          Abstract

          Use of an alternative open reading frame, potentially as a result of cellular stress, drives production of an unconventional insulin epitope that is recognized by cytotoxic T cells from individuals with type 1 diabetes; these T cells kill beta cells in vitro.

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          Author and article information

          Journal
          Nature Medicine
          Nat Med
          Springer Nature
          1078-8956
          1546-170X
          February 27 2017
          February 27 2017
          :
          :
          Article
          10.1038/nm.4289
          28263308
          00ca91b3-a023-4a90-ade5-ec37ea687d9c
          © 2017
          History

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