Influence of Chronic Diuretic Therapy on Serum, Lymphocyte and Erythrocyte Potassium, Magnesium and Calcium Concentrations

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Abstract

Serum, lymphocyte and erythrocyte potassium, magnesium and calcium concentrations were measured in 31 patients with congestive cardiac failure and 14 patients with mild noncomplicated hypertension, who had been receiving either furosemide or chlorothia-zide (with or without potassium supplementation) or a combination of hydrochlorothiazide and amiloride for more than 6 months. Lymphocyte potassium concentrations (pmol/l00 cells ± SE) were as follows: controls 18.1 ± 1.5, furosemide 14.1 ± 0.9 (p < 0.001), furosemide + potassium 12.3 ± 0.7 (p < 0.001), chlorothiazide 13.1 ± 1.0 (p < 0.001) and hydrochlorothiazide + amiloride 18.6 ± 0.7 (p = NS). There was a statistically significant relationship between the number of months the patients had been on diuretics and their lymphocyte potassium concentrations. Serum electrolytes, apart from the group receiving chlorothiazide who showed a significant fall in serum K, were unchanged.

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1988

Publication date (Print): 1988

Publication date (Electronic): 11 November 2008

Volume: 75

Issue: 1

Pages: 17-23

Affiliations

Departments of ^aMedicine, ^bCardiology and ^cClinical Biochemistry, Shaare Zedek Medical Center, Jerusalem, Israel

Article

Publisher ID: 174345 Other ID: Cardiology 1988;75:17–23

DOI: 10.1159/000174345

PubMed ID: 3342421

SO-VID: 00df17a8-b47d-43d0-a9ce-44af0b8a924e

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 05 December 1986

Date accepted : 12 February 1987

Page count

Pages: 7

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