Ultrasound-responsive NIPAM-based hydrogels with tunable profile of controlled release of large molecules.

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Abstract

Episodic release of bioactive compounds plays an important role in biological systems. "On-demand" release systems which based on polymeric materials and activated by external stimuli may provide the necessary functionality. Here we describe an ultrasound-responsive hydrogel based on N-isopropylacrylamide (NIPAM) and N,N'-methylenebisacrylamide (MBAm), which is suitable for triggered release of two large molecules: bovine serum albumin (BSA, 66kDa) and dextran (3-5kDa). It is shown that the release amount of these two large molecules increased with increasing hydrogel temperature, and the application of ultrasound further increased the release. By simply adjusting the contents of NIPAM and MBAm, the difference of BSA release between the presence and absence of ultrasound could be adjusted from 2.7 to 84 folds. There was also a positive correlation between the ultrasound intensity and release amount. These properties made the NIPAM-based hydrogel a tunable platform for focal drug delivery.

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Author and article information

Journal

Journal ID (iso-abbrev): Ultrasonics

Title: Ultrasonics

Publisher: Elsevier BV

ISSN (Electronic): 1874-9968

ISSN (Print): 0041-624X

Publication date (Electronic): Feb 2018

Volume: 83

Affiliations

[1 ] Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan.

[2 ] Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan.

[3 ] Department of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan.

[4 ] Department of Civil Engineering, National Taiwan University, Taipei, Taiwan.

[5 ] Department of Civil Engineering, Chung Yuan Christian University, Taoyuan, Taiwan.

[6 ] Department of Chemical Engineering, National Taiwan University, Taipei, Taiwan; Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan.

[7 ] Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

[8 ] Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan. Electronic address: thyoung@ntu.edu.tw.

Article

Publisher Item ID: S0041-624X(16)30391-2

DOI: 10.1016/j.ultras.2017.03.019

PubMed ID: 28408049

SO-VID: 00ec0d1b-1ac9-4128-b9c6-db79d6b4d37e

Keywords: Controlled release,Hydrogel,Temperature dependence,Ultrasound

Data availability:

Keywords: Controlled release, Hydrogel, Temperature dependence, Ultrasound

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