1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear. The frequency of circulating Tfr and Tfh cells were examined in SLE patients and healthy controls. The frequency of circulating Tfr cell decreased and Tfh/Tfr ratio increased in SLE patients. Serum anti-dsDNA antibody level positively correlated with frequency of Tfh cells and Tfh/Tfr ratios but negatively correlated with the frequency of Tfr cells. Moreover, the frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. In addition, increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments. Thus, Tfr cells should be considered as a biomarker for SLE and their role in the pathogenesis of SLE warrants further investigation.

          Related collections

          Author and article information

          Journal
          100883537
          21167
          Clin Immunol
          Clin. Immunol.
          Clinical immunology (Orlando, Fla.)
          1521-6616
          1521-7035
          28 September 2017
          12 July 2017
          October 2017
          07 November 2017
          : 183
          : 46-53
          Affiliations
          [a ]Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China
          [b ]Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China
          [c ]Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908-0133, USA
          [d ]Division of Rheumatology and Center of Inflammation, Immunology and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908-0133, USA
          [e ]Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908-0133, USA
          Author notes
          [* ]Corresponding author: zsuyns@ 123456163.com (N. Yang)
          [1]

          These authors contributed equally to this work.

          Article
          PMC5673570 PMC5673570 5673570 nihpa909529
          10.1016/j.clim.2017.07.004
          5673570
          28709914
          Categories
          Article

          Biomarker, Tfh, Tfr, SLE

          Comments

          Comment on this article