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      Psychological Well-Being before and after Growth Hormone Treatment in Adults with Growth Hormone Deficiency

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          The effect of recombinant-DNA human growth hormone treatment on psychological well-being and quality of life was studied in adults with GH deficiency (GHD). 24 adults who satisfied strict criteria for GHD took part in a double-blind, placebo-controlled, 6-month trial. Quality of life assessments were performed at entry, 1 and 6 months by means of self-rating questionnaires. This study reports significantly lower scores on quality of life assessment in the GH-deficient patients at entry compared with matched controls, indicating that this population may be psychologically compromised. Preliminary analysis of treatment results shows that after 6 months, those patients receiving active treatment experienced less perceived illness than the placebo group. Significant psychological improvements were noted in the patients’ perception of their energy level and mood.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 33
          : Suppl 4
          : 52-54
          aDepartment of Medicine, Endocrine Unit, United Medical and Dental School of Guy’s and St. Thomas’ Hospitals, St. Thomas Hospital, London, UK; bUniversity Hospital, Zurich, Switzerland
          181584 Horm Res 1990;33:52–54
          © 1990 S. Karger AG, Basel

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          Pages: 3
          The Seville hGH Symposium


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