Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy.

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Abstract

Cultured human corneal endothelial cells (cHCECs) are anticipated to become an alternative to donor corneas for the treatment of corneal endothelial dysfunction. The aim of this study was to establish proper culture protocols to successfully obtain a reproducibly homogeneous subpopulation (SP) with matured cHCEC functions and devoid of cell-state transition suitable for cell-injection therapy.

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Journal

Journal ID (iso-abbrev): Invest. Ophthalmol. Vis. Sci.

Title: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): April 01 2017

Volume: 58

Issue: 4

Affiliations

[1 ] Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

[2 ] Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

[3 ] SightLife Surgical, Inc., Seattle, Washington, United States.

Article

Publisher Item ID: 2617369

DOI: 10.1167/iovs.16-20703

PubMed ID: 28384722

SO-VID: 010ecc05-8336-4f0b-a90d-d0e00dae20c9

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