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      Lingual thyroid gland: it’s time for awareness

      research-article
      1 , 1 , 2 , 2 , 3 , 1 , 1 , 1
      Endocrinology, Diabetes & Metabolism Case Reports
      Bioscientifica Ltd
      Adult, Female, Hispanic or Latino - Puerto Rican, Puerto Rico, Thyroid, Thyroid, TSH, Thyroxine (T4), Hypothyroidism, Lingual thyroid*, Ectopic thyroid tissue*, Dysphagia, Dysphonia, Lingual thyroid*, Ectopic thyroid tissue*, Hypothyroidism, TSH, Total T4, Laryngoscopy*, Thyroid scintigraphy, Thyroid ultrasonography, Histopathology, CT scan, Radionuclide imaging, Levothyroxine, Otolaryngology, Unique/unexpected symptoms or presentations of a disease, May, 2020

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          Abstract

          Summary

          Lingual thyroid (LT) gland is the most common type of ectopic thyroid tissue, but it is an extremely rare presentation. We present a case of a 41-year-old Hispanic female patient complaining of dysphonia and dysphagia. As part of the evaluation, fiber optic flexible indirect laryngoscopy (FIL) was performed which revealed a mass at the base of the tongue. The morphological examination was highly suspicious for ectopic thyroid tissue and the diagnosis was confirmed with neck ultrasound and thyroid scintigraphy. Although the patient presented subclinical hypothyroidism, levothyroxine therapy was initiated with a favorable response which included resolution of symptoms and mass size reduction. Our case portrays how thyroid hormone replacement therapy (THRT) may lead to a reduction in the size of the ectopic tissue and improvement of symptoms, thus avoiding the need for surgical intervention which could result in profound hypothyroidism severely affecting the patients’ quality of life.

          Learning points:
          • Benign LT and malignant LT are indistinguishable clinically and radiographically for which histopathology is recommended.

          • THRT, radioactive iodine 131 (RAI) therapy, and surgical excision are potential management options for LT.

          • THRT may lead to size reduction of the ectopic tissue and resolution of symptoms avoiding surgical intervention.

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          Most cited references10

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          Thyroid development and its disorders: genetics and molecular mechanisms.

          Thyroid gland organogenesis results in an organ the shape, size, and position of which are largely conserved among adult individuals of the same species, thus suggesting that genetic factors must be involved in controlling these parameters. In humans, the organogenesis of the thyroid gland is often disturbed, leading to a variety of conditions, such as agenesis, ectopy, and hypoplasia, which are collectively called thyroid dysgenesis (TD). The molecular mechanisms leading to TD are largely unknown. Studies in murine models and in a few patients with dysgenesis revealed that mutations in regulatory genes expressed in the developing thyroid are responsible for this condition, thus showing that TD can be a genetic and inheritable disease. These studies open the way to a novel working hypothesis on the molecular and genetic basis of this frequent human condition and render the thyroid an important model in the understanding of molecular mechanisms regulating the size, shape, and position of organs.
            • Record: found
            • Abstract: not found
            • Article: not found

            Ectopic thyroid: etiology, pathology and management.

              • Record: found
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              • Article: not found

              Clinical characteristics of ectopic thyroid in Korea.

              Ectopic thyroid is a rare entity and can occur at any location in the midline position. A role for the ectopic thyroid in the pathogenesis of hypothyroidism and nongoitrous cretinism has been emphasized. To assess the clinical characteristics of an ectopic thyroid by analyzing 49 cases reported in Korea. This study was a retrospective review of 19 cases who were diagnosed by thyroid scan at our institutions together with 30 cases reported in the Korean medical literature, found using KoreaMed. Most cases of ectopic thyroid were diagnosed in patients aged between 1 and 29 years; it was more common in females (43 patients). A lingual thyroid was found in 23 patients, a sublingual thyroid in 17 patients, combined type in 7 patients, a prelaryngeal thyroid in 1 patient, and an intratracheal thyroid in 1 patient. Only four cases had the thyroid gland in the normal position. The chief complaints at presentation were palpable mass in 20 patients, growth retardation in 10 patients, and a lump sensation in the throat in 6 patients. Twenty-six of 42 patients (61.9%) had hypothyroidism, and 16 patients (38.1%) had euthyroidism. As for the treatment modalities, 18 of 26 patients with hypothyroidism and 4 of 16 patients with normal thyroid function received thyroid hormone medication; 3 of 26 patients with hypothyroidism and 8 of 16 patients with euthyroidism underwent resection of the ectopic thyroid. Our study suggests that radionuclide thyroid scanning and function testing may be useful not only for the diagnosis of an ectopic thyroid but also before deciding on the therapeutic modality; patients should be followed up to detect changes in thyroid function and malignant transformation.

                Author and article information

                Journal
                Endocrinol Diabetes Metab Case Rep
                Endocrinol Diabetes Metab Case Rep
                EDM
                Endocrinology, Diabetes & Metabolism Case Reports
                Bioscientifica Ltd (Bristol )
                2052-0573
                29 May 2020
                2020
                : 2020
                : EDM20-0026
                Affiliations
                [1 ]Endocrinology Department , San Juan City Hospital, San Juan, Puerto Rico
                [2 ]Internal Medicine Department , San Juan City Hospital, San Juan, Puerto Rico
                [3 ]Otolaryngology Head and Neck Surgery , University of Puerto Rico, Medical Science Campus, San Juan, Puerto Rico
                Author notes
                Correspondence should be addressed to N Cruz-Dardíz; Email: nicocruz85@ 123456hotmail.com
                Article
                EDM200026
                10.1530/EDM-20-0026
                7274546
                32478670
                01112644-531e-4fb6-b3c3-3fc4c8e2000e
                © 2020 The authors

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License..

                History
                : 02 March 2020
                : 28 April 2020
                Categories
                Adult
                Female
                Hispanic or Latino - Puerto Rican
                Puerto Rico
                Thyroid
                Thyroid
                TSH
                Thyroxine (T4)
                Hypothyroidism
                Lingual thyroid*
                Ectopic thyroid tissue*
                Dysphagia
                Dysphonia
                Lingual thyroid*
                Ectopic thyroid tissue*
                Hypothyroidism
                TSH
                Total T4
                Laryngoscopy*
                Thyroid scintigraphy
                Thyroid ultrasonography
                Histopathology
                CT scan
                Radionuclide imaging
                Levothyroxine
                Otolaryngology
                Unique/Unexpected Symptoms or Presentations of a Disease
                Unique/Unexpected Symptoms or Presentations of a Disease

                adult,female,hispanic or latino - puerto rican,puerto rico,thyroid,tsh,thyroxine (t4),hypothyroidism,lingual thyroid*,ectopic thyroid tissue*,dysphagia,dysphonia,total t4,laryngoscopy*,thyroid scintigraphy,thyroid ultrasonography,histopathology,ct scan,radionuclide imaging,levothyroxine,otolaryngology,unique/unexpected symptoms or presentations of a disease,may,2020

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