L-Type Cav 1.2 Calcium Channel-α-1C Regulates Response to Rituximab in Diffuse Large B-Cell Lymphoma.

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Abstract

One third of patients with diffuse large B-cell lymphoma (DLBCL) succumb to the disease partly due to rituximab resistance. Rituximab-induced calcium flux is an important inducer of apoptotic cell death, and we investigated the potential role of calcium channels in rituximab resistance.

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Journal

Journal ID (iso-abbrev): Clin. Cancer Res.

Title: Clinical cancer research : an official journal of the American Association for Cancer Research

Publisher: American Association for Cancer Research (AACR)

ISSN: 1078-0432

ISSN (Print): 1078-0432

Publication date (Electronic): Jul 01 2019

Volume: 25

Issue: 13

Affiliations

[1 ] Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China.

[2 ] Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.

[3 ] Department of Molecule and Pathology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China.

[4 ] China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan, China.

[5 ] Department of Pathophysiology, Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China.

[6 ] Department of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska.

[7 ] Department of Pathology, City of Hope National Medical Center, Duarte, California.

[8 ] Department of Pathology, City of Hope National Medical Center, Duarte, California. liuyanyan4827@yahoo.com jiqbal@unmc.edu jochan@coh.org.

[9 ] Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska. liuyanyan4827@yahoo.com jiqbal@unmc.edu jochan@coh.org.

[10 ] Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, China. liuyanyan4827@yahoo.com jiqbal@unmc.edu jochan@coh.org.

Article

Publisher Item ID: 1078-0432.CCR-18-2146

DOI: 10.1158/1078-0432.CCR-18-2146

PubMed ID: 30824586

SO-VID: 0114294a-c225-4e1a-90d8-00a16bc4e54f

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