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      Partial Deficiency of Thyroxine-Binding Globulin: An HLA Study

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          Partial thyroxine-binding globulin (TBG) deficiency, with a median TBG of 2.3 mg/l, was found in 25 mature babies with hypothyroxinaemia (3 girls and 22 boys) from our screening programme for congenital hypothyroidism during 1988-1990. Analysis of the HLA system revealed the possibility that antigen DR6 may be considered as a risk factor for TBG deficiency (44.0 vs. 19.2%) and DR2 as a protective factor (16.0 vs. 37.5%). Similar laboratory findings were also present in 16 mothers and 1 father.

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          Hormone Research in Paediatrics
          S. Karger AG
          05 December 2008
          : 40
          : 5-6
          : 201-203
          aClinic of Children and Adolescents, 3rd Medical Faculty, Charles University; and bDepartment of Immunology, Institute of Clinical and Experimental Medicine, Prague, Czech Republic
          183795 Horm Res 1993;40:201–203
          © 1993 S. Karger AG, Basel

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