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      Partial Deficiency of Thyroxine-Binding Globulin: An HLA Study

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          Abstract

          Partial thyroxine-binding globulin (TBG) deficiency, with a median TBG of 2.3 mg/l, was found in 25 mature babies with hypothyroxinaemia (3 girls and 22 boys) from our screening programme for congenital hypothyroidism during 1988-1990. Analysis of the HLA system revealed the possibility that antigen DR6 may be considered as a risk factor for TBG deficiency (44.0 vs. 19.2%) and DR2 as a protective factor (16.0 vs. 37.5%). Similar laboratory findings were also present in 16 mothers and 1 father.

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          Author and article information

          Journal
          HRE
          10.1159/issn.0018-5051
          Hormone Research in Paediatrics
          S. Karger AG
          0018-5051
          2571-6603
          1993
          1993
          05 December 2008
          : 40
          : 5-6
          : 201-203
          Affiliations
          aClinic of Children and Adolescents, 3rd Medical Faculty, Charles University; and bDepartment of Immunology, Institute of Clinical and Experimental Medicine, Prague, Czech Republic
          Article
          183795 Horm Res 1993;40:201–203
          10.1159/000183795
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 3
          Categories
          Original Paper

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