Nishtha Jhilmeet: Role: Data curationRole: Formal analysisRole: Funding acquisitionRole: Writing – original
draftRole: Writing – review & editing
David M. Lowe:
ORCID: http://orcid.org/0000-0001-6102-2375
Role: ConceptualizationRole: Data curationRole: ResourcesRole: Writing – original
draftRole: Writing – review & editing
Catherine Riou: Role: Data curationRole: Writing – review & editing
Thomas J. Scriba: Role: ConceptualizationRole: ResourcesRole: Writing – review & editing
Anna Coussens:
ORCID: http://orcid.org/0000-0002-7086-2621
Role: Formal analysisRole: Writing – review & editing
Rene Goliath: Role: Project administration
Robert J. Wilkinson: Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Katalin Andrea Wilkinson:
ORCID: http://orcid.org/0000-0002-9796-2040
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
Project administrationRole: SupervisionRole: Writing – original draftRole: Writing
– review & editing
Olivier Neyrolles: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
27
December
2018
Publication date Collection: 2018
Volume: 13
Issue: 12
Electronic Location Identifier: e0209516
Affiliations
[1
]
Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious
Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
[2
]
South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and
Molecular Medicine, University of Cape Town, Cape Town, South Africa
[3
]
Department of Pathology, University of Cape Town, Cape Town, South Africa
[4
]
Department of Medicine, University of Cape Town, Cape Town, South Africa
[5
]
The Francis Crick Institute, London, United Kingdom
[6
]
Department of Medicine, Imperial College London, London, United Kingdom
Institut de Pharmacologie et de Biologie Structurale, FRANCE
Author notes
Competing Interests: The authors have declared that no competing interests exist.
[¤a]
Current address: Institute of Immunity and Transplantation, University College London,
Royal Free Campus, London, United Kingdom
[¤b]
Current address: Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Author information
Article
Publisher ID:
PONE-D-18-28678
DOI: 10.1371/journal.pone.0209516
PMC ID: 6307796
PubMed ID: 30589870
SO-VID: 01269000-68c5-43fa-a1ff-4317f2de811a
Copyright © © 2018 Jhilmeet et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
Award ID: 104803
Award Recipient
:
Robert J. Wilkinson
Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
Award ID: 087754
Award Recipient
:
Robert J. Wilkinson
Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
Award ID: 203135
Award Recipient
:
Robert J. Wilkinson
Funded by: funder-id http://dx.doi.org/10.13039/501100007601, Horizon 2020;
Award ID: 643381
Award Recipient
:
Robert J. Wilkinson
Research supported by The Wellcome Trust (104803, 087754, 203135) to RJW, The South
African National Research Foundation (443386), the European Union Horizon 2020 research
and innovation programme under grant agreement No 643381 to RJW and The Francis Crick
Institute which receives support from UKRI (FC001218), Cancer Research UK (FC001218)
and Wellcome (FC001218). The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Actinobacteria
Subject:
Mycobacterium Tuberculosis
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Blood cells
Subject:
White blood cells
Subject:
T cells
Subject:
Memory T cells
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Memory T cells
Subject:
Biology and life sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Memory T cells
Subject:
Medicine and health sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Memory T cells
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Bacterial Diseases
Subject:
Tuberculosis
Subject:
Medicine and Health Sciences
Subject:
Tropical Diseases
Subject:
Tuberculosis
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Medicine and health sciences
Subject:
Infectious diseases
Subject:
Viral diseases
Subject:
HIV infections
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1