Pd-Catalyzed C(sp(3))-H Carbonylation of Alkylamines: A Powerful Route to γ-Lactams and γ-Amino Acids.

Abstract

A novel Pd-catalyzed direct C(sp(3))-H carbonylation of alkylamines for the synthesis of γ-lactams and γ-amino acids has been developed, in which TEMPO was used as the crucial sole oxidant. The synthetic prospect was demonstrated by the concise total synthesis of rac-Pregbalin.