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      Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

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          Abstract

          <p class="first" id="d3357447e305">Short-term results support antibiotics as an alternative to surgery for treating uncomplicated acute appendicitis, but long-term outcomes are not known. </p>

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          Most cited references 7

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          Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Systematic Review and Meta-analysis of Controlled Trials (PROSPERO 2015: CRD42015016882).

          The aim was to investigate available evidence regarding effectiveness and safety of surgical versus conservative treatment of acute appendicitis.
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            Comparison of Antibiotic Therapy and Appendectomy for Acute Uncomplicated Appendicitis in Children: A Meta-analysis.

            Antibiotic therapy for acute uncomplicated appendicitis is effective in adult patients, but its application in pediatric patients remains controversial.
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              Antibiotics Versus Appendicectomy for the Treatment of Uncomplicated Acute Appendicitis: An Updated Meta-Analysis of Randomised Controlled Trials.

              Uncomplicated acute appendicitis has been managed traditionally by early appendicectomy. However, recently, there has been increasing interest in the potential for primary treatment with antibiotics, with studies finding this to be associated with fewer complications than appendicectomy. The aim of this study was to compare outcomes of antibiotic therapy with appendicectomy for uncomplicated acute appendicitis.
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                Author and article information

                Journal
                JAMA
                JAMA
                American Medical Association (AMA)
                0098-7484
                September 25 2018
                September 25 2018
                : 320
                : 12
                : 1259
                Affiliations
                [1 ]Division of Digestive Surgery and Urology, Department of Digestive Surgery, Turku University Hospital, University of Turku, Turku, Finland
                [2 ]Department of Surgery, University of Turku, Turku, Finland
                [3 ]Department of Public Health, University of Turku, Turku, Finland
                [4 ]Primary Health Care Unit, Hospital District of Southwest Finland, Turku, Finland
                [5 ]University of Namibia, Windhoek, Namibia
                [6 ]Department of Surgery, Mikkeli Central Hospital, Mikkeli, Finland
                [7 ]Department of Surgery, Oulu University Hospital, Oulu, Finland
                [8 ]Division of Surgery, Gastroenterology, and Oncology, Tampere University Hospital, Tampere, Finland
                [9 ]Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland
                [10 ]Department of Surgery, Kuopio University Hospital, Kuopio, Finland
                [11 ]Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
                [12 ]Department of Surgery, Seinäjoki Central Hospital, Seinäjoki, Finland
                [13 ]Department of Biostatistics, University of Turku, Turku, Finland
                [14 ]Department of Surgery, Central Hospital of Central Finland, Jyväskylä, Finland
                [15 ]Department of Sport and Health Sciences, Jyväskylä University, Jyväskylä, Finland
                [16 ]Department of Health and Medical Services, Päijät-Häme Joint Authority for Health and Wellbeing, Lahti, Finland
                [17 ]Department of Radiology, Turku University Hospital, Turku, Finland
                [18 ]Department of Radiology, Oulu University Hospital, Oulu, Finland
                Article
                10.1001/jama.2018.13201
                6233612
                30264120
                © 2018

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