Introduction. The International Council of Nurses has had an important role in enforcing of the regulation of the occupation of the Nurse. The Council established 11 basic principles of regulation based on their importance. The aim is to present the implementation of the International Council of Nurses in Slovakia and their intentions and to characterize the forms and methods of regulations of this occupation. This work also aims to analyze the legislative base of the process and refer to the importance of self-regulatory mechanisms. Our intention is to familiarize the reader with creation; development; maintenance of mandatory registration of Nurses in Slovakia. Results. Concessions, registration, certification and accreditation of people or programs are the mechanisms of regulation. Regulation of the Nurses’ occupation in Slovakia takes place in the form of self-regulation or statutory regulation. The basic tool of self-regulation is the Ethical Codex, which defines the responsibility of Nurses towards people – patients and also towards practice, profession, co-workers and society. A Nurse takes on the moral commitment that she/he will observe the values and fulfil the moral responsibilities expressed in the Codex. Codex as a self-regulatory mechanism expresses the aims and values of the nursing occupation. In practice, this means that the Nurse binds herself/himself to support health, prevent diseases, recover and maintain health and ease the suffering. Statutory regulation is set by legal norms and has a form of state registration, it is governed by the government and as realized by the Slovak Chamber of Nurses and Midwives. The tool for statutory regulation is obligatory registration. Based on Law no. 578/2004 of the Codex of Healthcare Providers, Healthcare Workers and State Organizations in Healthcare - § 62 section 1 – Registration is the entry of a Nurse to Register and issuing a confirmation of Registration. It is important in national and international context. In a national context, it defines who and under what conditions are eligible to work as a Nurse. In international context, it conditions the ability to find employment on the international labor market. Registration is mandatory in Slovakia since 2004.