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      Halioxepine, a new meroditerpene from an Indonesian sponge Haliclona sp.

      Chemical & pharmaceutical bulletin
      Animals, Antineoplastic Agents, analysis, chemistry, isolation & purification, pharmacology, Biological Factors, Cell Line, Tumor, Diterpenes, Drug Evaluation, Preclinical, Drug Screening Assays, Antitumor, Haliclona, Molecular Structure, Stereoisomerism

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          Abstract

          Chemical investigations on a sponge Haliclona sp. found a meroditerpene 1 having a new carbon skeleton. By analyzing spectroscopic data, the structure was elucidated to comprise a substituted hydroquinone, a tetrahydrooxepine, and a cyclohexene, and these components were united with C1 and C2 units. Compound 1 showed moderate cytotoxicity against NBT-T2 cells with IC50 4.8 µg/ml and also antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 3.2 µg/ml.

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