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      Inflammatory bowel disease in patients with Hirschsprung's disease: a systematic review and meta-analysis.

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          Abstract

          Hirschsprung-associated enterocolitis (HAEC) continues to be an important cause of morbidity in patients with Hirschsprung's disease (HSCR). HAEC can occur at any time during the course of the disease. The reported incidence of HAEC before surgery ranges from 6 to 50%, and after surgery, it ranges from 2 to 35%. HAEC and inflammatory bowel disease (IBD) have similar clinical presentation including diarrhea, hematochezia, and abdominal pain. In recent years, isolated cases of IBD have been reported in patients who had surgical treatment for HSCR. The exact pathogenesis of HAEC or IBD is not known. However, both conditions are characterized by an abnormal intestinal mucosal barrier function, which may be a common pathway. The purpose of this meta-analysis was to determine the clinical presentation and outcome in patients with HSCR who developed IBD after pull-through operation.

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          Author and article information

          Journal
          Pediatr. Surg. Int.
          Pediatric surgery international
          Springer Science and Business Media LLC
          1437-9813
          0179-0358
          Feb 2018
          : 34
          : 2
          Affiliations
          [1 ] National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland.
          [2 ] Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.
          [3 ] National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland. prem.puri@ncrc.ie.
          [4 ] School of Medicine and Medical Science and Conway Institute of Biomolecular and Biomedical Research University College Dublin, Dublin, Ireland. prem.puri@ncrc.ie.
          Article
          10.1007/s00383-017-4182-4
          10.1007/s00383-017-4182-4
          28983688

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