Elevated Divalent Ion Concentrations in Parotid Saliva from Chronic Renal Failure Patients

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Abstract

Mg and PO<sub>4</sub> concentrations were significantly higher in unmixed parotid saliva from chronic renal failure (CRF) patients than in controls. No significant differences were noted in the flow, pH or concentrations of Na, K, Cl or Ca; however, the Na/K ratio was significantly lower in CRF patients. No correlation between plasma PTH levels and the concentrations of Ca, Mg, or PO<sub>4</sub> in saliva was found. Taken with previous results from elevated divalent ion concentrations in sweat from CRF patients, these findings suggest that the excretion of divalent electrolyte glands may represent a generalized abnormality in exocrine glands in CRF. We hypothesize that the active processes involved in regulating the concentrations of these ions in exocrine secretions are altered so that larger amounts of these elements are excreted in CRF patients.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1981

Publication date (Print): 1981

Publication date (Electronic): 02 December 2008

Volume: 28

Issue: 2

Pages: 58-61

Affiliations

Division of Nephrology, Departments of Medicine and Physiology, UCLA Medical School, Los Angeles, Calif., USA; Division of Biomedical Sciences, University of California, Riverside, Calif., USA

Article

Publisher ID: 182107 Other ID: Nephron 1981;28:58–61

DOI: 10.1159/000182107

PubMed ID: 7290272

SO-VID: 014ad9cc-8c7b-4482-9123-ef9576c59104

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 08 October 1980

Page count

Pages: 4

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