- Record: found
- Abstract: not found
- Article: not found
A light in multidrug resistance: Photodynamic treatment of multidrug-resistant tumors
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d21507888e64">The major drawback of cancer chemotherapy is the
development of multidrug-resistant
(MDR) tumor cells, which are cross-resistant to a broad range of structurally and
functionally unrelated agents, making it difficult to treat these tumors. In the last
decade, a number of authors have studied the effects of photodynamic therapy (PDT),
a combination of visible light with photosensitizing agents, on MDR cells. The results,
although still inconclusive, have raised the possibility of treating MDR tumors by
PDT. This review examines the growing literature concerning the responses of MDR cells
to PDT, while stressing the need for the development of new photosensitizers that
possess the necessary characteristics for the photodynamic treatment of this class
of tumor.
</p>