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      Metalloproteases: carving out a role in axon guidance.

      Neuron
      Amyloid Precursor Protein Secretases, Animals, Aspartic Acid Endopeptidases, Axons, physiology, Drosophila, Endopeptidases, metabolism, Growth Cones, Ligands, Matrix Metalloproteinases, Metalloendopeptidases, antagonists & inhibitors, Mice, Nerve Tissue Proteins, Receptors, Immunologic, Signal Transduction, Superior Colliculi, cytology, embryology, Visual Pathways

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          Abstract

          Two families of metalloproteases, the matrix metalloproteases (MMPs) and the A Disintegrin and Metalloproteases (ADAMs), have recently been implicated in the formation of neural connections in the developing central nervous system. Invertebrate and vertebrate axons fail to extend and/or make pathfinding errors when metalloprotease function is inhibited or absent. Culture studies suggest that this requirement for metalloprotease activity results from their ability to cleave ligands, or their receptors, so as to activate or inhibit specific axon extension or guidance signaling pathways.

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