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      Effect of Acute Intravenous Growth Hormone-Releasing Factor on Plasma Prolactin in Short Children and Patients with Growth Hormone Deficiency

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          Abstract

          Four normal subjects and 54 growth hormone (GH)-deficient patients including 43 children with growth failure were given an intravenous bolus of growth hormone-releasing factor (GHRF). Plasma prolactin (Prl) and GH after GHRF were studied. Basal plasma Prl was either normal or elevated and could not predict the GH response to GHRF. A correlation was found, within the group with basal hyperprolactinemia, between basal Prl and the net Prl increase after GHRF. No correlation was found between the net GH and the net Prl increase after GHRF. Plasma Prl was significantly, although weakly, increased after GHRF in the normal subjects.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-4415-3
          978-3-318-05738-6
          1663-2818
          1663-2826
          1985
          1985
          26 November 2008
          : 22
          : 1-2
          : 46-51
          Affiliations
          aINSERM U. 34, Hôpital Debrousse, Lyon, France; bHôpital Neurologique, Lyon, France; cDepartment of Pediatrics, UER A.-Carrel, Hôpital E.-Herriot, Lyon, France; dHôpital Cardiologique, Lyon, France; eDepartment of Pediatrics, Hôpital Debrousse, Lyon, France
          Article
          180070 Horm Res 1985;22:46–51
          10.1159/000180070
          3928476
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Pediatric Endocrinology

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