16 December 2015
retinoic acid-related orphan receptor, RORγ, RORα, RORβ, immunity, Th17 cells, innate lymphoid cells, autoimmune disease, retina, brain, cancer, metabolism, glucose homeostasis, lipid metabolism, insulin sensitivity, diabetes, circadian clock, agonists, cholesterol biosynthesis, autism, agonists, antagonist, transcription
In this overview, we provide an update on recent progress made in understanding the mechanisms of action, physiological functions, and roles in disease of retinoic acid related orphan receptors (RORs). We are particularly focusing on their roles in the regulation of adaptive and innate immunity, brain function, retinal development, cancer, glucose and lipid metabolism, circadian rhythm, metabolic and inflammatory diseases and neuropsychiatric disorders. We also summarize the current status of ROR agonists and inverse agonists, including their regulation of ROR activity and their therapeutic potential for management of various diseases in which RORs have been implicated.