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      The Potential Relevances of Biology to Social Inquiry

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      Annual Review of Sociology
      Annual Reviews

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          Natural Selection of Parental Ability to Vary the Sex Ratio of Offspring

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            Serotonin transporter genetic variation and the response of the human amygdala.

            A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent. Serotonin [5- hydroxytryptamine, (5-HT)] function influences normal fear as well as pathological anxiety, behaviors critically dependent on the amygdala in animal models and in clinical studies. We now report that individuals with one or two copies of the short allele of the serotonin transporter (5-HTT) promoter polymorphism, which has been associated with reduced 5-HTT expression and function and increased fear and anxiety-related behaviors, exhibit greater amygdala neuronal activity, as assessed by BOLD functional magnetic resonance imaging, in response to fearful stimuli compared with individuals homozygous for the long allele. These results demonstrate genetically driven variation in the response of brain regions underlying human emotional behavior and suggest that differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele.
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              In Search of Homo Economicus: Behavioral Experiments in 15 Small-Scale Societies

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                Author and article information

                Journal
                Annual Review of Sociology
                Annu. Rev. Sociol.
                Annual Reviews
                0360-0572
                1545-2115
                August 2003
                August 2003
                : 29
                : 1
                : 233-256
                Article
                10.1146/annurev.soc.29.010202.100012
                01b229d6-0336-4425-8a0d-ccb2afc8d624
                © 2003
                History

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