Contribution of acute-phase proteins and cardiovascular risk factors to erythrocyte aggregation in normolipidemic and hyperlipidemic individuals.

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Abstract

Numerous studies have demonstrated that elevated concentrations of acute-phase proteins affect red blood cell (RBC) aggregation. Plasma lipids and lipoproteins were also shown to be correlated with RBC aggregation in hypercholesterolemia. However, whether acute-phase proteins promote RBC hyperaggregation in hyperlipidemic patients is unknown. The main objective of the study was to identify the impact of acute-phase proteins such as fibrinogen (Fib), haptoglobin (Hp), ceruloplasmin (Cp), alpha1-acid glycoprotein (AGP), alpha1-antitrypsin (AT), immunoglobulin G (IgG), and albumin (Alb) on RBC aggregation in 35 hyperlipidemic patients. The influence of these proteins in 32 normolipidemic subjects was also determined.

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Journal

Journal ID (iso-abbrev): Thromb. Haemost.

Title: Thrombosis and haemostasis

ISSN: 0340-6245

ISSN (Print): 0340-6245

Publication date (Electronic): Dec 1998

Volume: 80

Issue: 6

Affiliations

[1 ] Laboratory of Biomedical Engineering, Clinical Research Institute of Montréal, Québec, Canada.

Article

Publisher Item ID: 98120903

PubMed ID: 9869158

SO-VID: 01b69bdc-e259-4bcf-92c5-51b2f3b4646f

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