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      Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.

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          Abstract

          Plasmalemmal Kv7.1 (KCNQ1) channels are critical players in cardiac excitability; however, little is known on the functional role of additional Kv7 family members (Kv7.2-5) in cardiac cells. In this work, the expression, function, cellular and subcellular localization, and potential cardioprotective role against anoxic-ischaemic cardiac injury of Kv7.4 channels have been investigated.

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          Author and article information

          Journal
          Cardiovasc. Res.
          Cardiovascular research
          Oxford University Press (OUP)
          1755-3245
          0008-6363
          May 01 2016
          : 110
          : 1
          Affiliations
          [1 ] Department of Pharmacy, University of Pisa, Pisa, Italy.
          [2 ] Department of Neuroscience, Division of Pharmacology, University of Naples 'Federico II', Naples, Italy Vascular Biology Research Centre, Institute of Cardiovascular and Cell Sciences, St George's University of London, London, UK.
          [3 ] Department of Medicine and Health Science "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
          [4 ] Department of Neuroscience, Division of Pharmacology, University of Naples 'Federico II', Naples, Italy.
          [5 ] Vascular Biology Research Centre, Institute of Cardiovascular and Cell Sciences, St George's University of London, London, UK.
          [6 ] Cardiovascular Division, Faculty of Life Sciences and Medicine, King's College London, London, UK.
          [7 ] Department of Neurosciences, University of the Basque Country UPV/EHU, Leioa, Spain.
          [8 ] Department of Neuroscience, Division of Pharmacology, University of Naples 'Federico II', Naples, Italy Department of Medicine and Health Science "Vincenzo Tiberio", University of Molise, Campobasso, Italy m.taglialatela@unimol.it.
          Article
          cvv281
          10.1093/cvr/cvv281
          26718475
          01bcd48b-e1b5-4e65-9a7b-fc1403e33ae7
          History

          Cardioprotection,Ischaemia–reperfusion cardiac damage,Kv7 potassium channels,Mitochondria,Retigabine

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