Relationship between inhibition of ongoing responses with attention deficit and behavior disorder

Abstract

Objective To examine the relationship between inhibition of ongoing responses deficit with attention deficit and behavior disorder among ADHD children.

Methods Totally 43 children with attention deficit hyperac tivity disorder (ADHD) aged 6–14 years who met the DSM–V criteria for ADHD were recruited. And 38 health children were recruited as the control group. Vision Continuous Performance Task (CPT) and Matching Familiar Figures Test were used to assess attention deficit and behavior disorder feature of the ADHD children. Stop-signal paradigm was used to assess the inhibition of ongoing responses.

Results In the stop-signal paradigm, the ADHD children’ s error rate was significantly higher than typically developing children ( t = 4.34, P < 0.01). The ADHD children error rate in the stop-signal task was positively correlated with the wrong number miss rate in CPT task ( r = 0.45, P<0.01), similar finding was observed in regression analysis, with inhibition of ongoing responses accounted for 20.1% of attention deficit ( t = 3.21, P<0.01). In ROC curve analysis, the cut-off sore was 15.50 in the task. The error rate in stop-signal task showed no association with miss rate in Matching Familiar Figures Test ( r = 0.09, P>0.05).

Conclusion Inhibition of ongoing responses among ADHD children is associated with attention deficit, but not with existence of behavior disorder.

Abstract

【摘要】 目的 探讨多动症 (attention deficit hyperactivity disorder, ADHD) 儿童的持续反应抑制缺陷与其注意水平和 冲动行为的关系, 为多动症认知功能康复训练提供参考。 方法 选取浙江省立同德医院就诊的 43 名诊断为多动症儿童和 36 名健康儿童为被试, 采用视觉持续性任务 (Visual CPT) 评估注意水平, 采用相似图形匹配 (MFFT) 任务评估冲动行为, 采 用停止信号任务 (咖 p-signal task, SST) 评估持续反应抑制。 结果 在 SST 中, ADHD 儿童的错误率高于对照组 ( t = 4.34, P <0.01)。SST 的错误率与 CPT 的漏报率相关有统计学意义 ( r = 0.45, P<0.01); 两者具有线性相关, 回归分析显示线性回归 有统计学意义 ( t = 3.21, P<0.01), 持续反应抑制能解释注意水平的20.1%。多动症儿童SST的错误率与MFFT的错误个数 相关无统计学意义 ( r = 0.09, P>0.05)。SST错误率受试者工作特征曲线下面积为0.77, 划界值为 15.5。 结论 多动症儿童 存在持续反应抑制缺陷, 持续抑制缺陷与注意缺陷存在正相关。被试在停止信号任务中的错误率若高于 15.5, 可考虑为多 动症。