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      Antiluminal Transport of L-Arginine and L-Leucine Following Microinjections in Peritubular Capillaries of the Rat

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      Nephron

      S. Karger AG

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          Abstract

          In order to determine the degree of exchange diffusion between the tubular cells of the rat kidney and the tubular lumen, microinjections of labeled amino acids and inulin have been carried out in peritubular capillaries. The animals were undergoing mannitol diuresis. Fractionated urinary collections were made from the ureters of both kidneys after each microinjection in order to determine the content in radioactivity. L-Arginine-<sup>14</sup>C and inulin-<sup>3</sup>H or L -leucine-<sup>3</sup>H and inulin-<sup>14</sup>C were injected. Our data show that: (1) Inulin excretion follows a similar pattern in both the control and the experimental kidney. (2) The amino acid excretion is almost as large in the control kidney as in the experimental one. However, the quantity found in the experimental kidney is always greater, this supplementary fraction being 2.0 ± 0.44% of the injected dose. (3) In experiments carried out under a perfusion of unlabeled amino acids, the supplementary fraction excreted by the experimental kidney increases slightly to 3.9 ± 1.03%. Our results indicate that the renal tubular cells are permeable from the basal membrane towards the tubular lumen; however, the fluxes in this direction are not as large as suggested by previous in vitro studies.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1971
          1971
          26 November 2008
          : 8
          : 4
          : 355-366
          Affiliations
          Département de Physiologie, Université de Montréal, Montréal
          Article
          179938 Nephron 1971;8:355–366
          10.1159/000179938
          5094851
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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