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      Successful treatment of leptomeningeal gliomatosis of pilomyxoid astrocytoma after failed frontline chemotherapy.

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          Abstract

          Pilomyxoid astrocytoma (PMA) is a rare variant of pilocytic astrocytoma. Compared with pilocytic astrocytoma, PMA is more aggressive, has a higher rate of local recurrence, and often disseminates to the leptomeninges. Leptomeningeal gliomatosis is another rare but often intractable neoplasm. PMA presenting as leptomeningeal gliomatosis can be a therapeutic challenge, particularly in young children for whom many pediatric oncologists consider radiation therapy only as a back-up treatment. However, chemotherapy, usually considered a frontline treatment for low-grade tumors such as PMA, has little impact on leptomeningeal gliomatosis.

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          Author and article information

          Journal
          Neurologist
          The neurologist
          2331-2637
          1074-7931
          Jan 2012
          : 18
          : 1
          Affiliations
          [1 ] Department of Neurosurgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, Japan. jintara@med.kurume-u.ac.jp
          Article
          00127893-201201000-00004
          10.1097/NRL.0b013e31823d7a92
          22217612
          01e7203d-7034-4dc5-b150-06bc4f40a60b
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