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      Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.

      Science (New York, N.Y.)

      Amino Acid Sequence, Animals, CHO Cells, Computational Biology, Conserved Sequence, Cricetinae, Eating, drug effects, Fasting, Gastric Emptying, Gastrointestinal Motility, Ghrelin, Humans, In Vitro Techniques, Ligands, Male, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Peptide Hormones, blood, chemistry, genetics, metabolism, pharmacology, physiology, Protein Binding, Protein Precursors, Radioimmunoassay, Rats, Rats, Sprague-Dawley, Receptors, G-Protein-Coupled, Receptors, Ghrelin, Signal Transduction, Weight Gain

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          Abstract

          Ghrelin, a circulating appetite-inducing hormone, is derived from a prohormone by posttranslational processing. On the basis of the bioinformatic prediction that another peptide also derived from proghrelin exists, we isolated a hormone from rat stomach and named it obestatin-a contraction of obese, from the Latin "obedere," meaning to devour, and "statin," denoting suppression. Contrary to the appetite-stimulating effects of ghrelin, treatment of rats with obestatin suppressed food intake, inhibited jejunal contraction, and decreased body-weight gain. Obestatin bound to the orphan G protein-coupled receptor GPR39. Thus, two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene. After differential modification, these hormones activate distinct receptors.

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          Journal
          16284174
          10.1126/science.1117255

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