Increased RANKL-mediated osteoclastogenesis by interleukin-1β and endoplasmic reticulum stress.

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Abstract

The mechanism by which IL-1β and thapsigargin (TG)-induced endoplasmic reticulum (ER) stress modulate the receptor activator of nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis remains elusive. Thus, we investigated the osteoclast-specific and ER signals in osteoclastogenesis of bone marrow-derived cells.

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Journal

Journal ID (iso-abbrev): Joint Bone Spine

Title: Joint, bone, spine : revue du rhumatisme

Publisher: Elsevier BV

ISSN (Electronic): 1778-7254

ISSN (Print): 1297-319X

Publication date (Electronic): Dec 2014

Volume: 81

Issue: 6

Affiliations

[1 ] Department of Internal Medicine, Medical School and Research Institute of Clinical Medicine, Chonbuk National University and Chonbuk, National University Hospital, Jeonju, Jeonbuk 561-712, South Korea.

[2 ] Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island, Kingston RI 02881, United States of America.

[3 ] Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, South Korea.

[4 ] Department of Anatomy, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea.

[5 ] Department of Internal Medicine, Medical School and Research Institute of Clinical Medicine, Chonbuk National University and Chonbuk, National University Hospital, Jeonju, Jeonbuk 561-712, South Korea. Electronic address: ywhim@jbnu.ac.kr.

Article

Publisher Item ID: S1297-319X(14)00132-8

DOI: 10.1016/j.jbspin.2014.04.012

PubMed ID: 24956991

SO-VID: 01f1bd34-38d0-491f-8f16-c1df78bfeffe

History

Keywords: Thapsigargin,IL-1β,Osteoclast,4-phenylbutyric acid,Endoplasmic reticulum stress

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Keywords: Thapsigargin, IL-1β, Osteoclast, 4-phenylbutyric acid, Endoplasmic reticulum stress

Increased RANKL-mediated osteoclastogenesis by interleukin-1β and endoplasmic reticulum stress.

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