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      Platelet to Lymphocyte Ratio in Cardiovascular Diseases: A Systematic Review

      1 , 2

      Angiology

      SAGE Publications

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          Abstract

          The platelet to lymphocyte ratio (PLR) is an integrated reflection of 2 opposite thrombotic/inflammatory pathways that are easily calculated from a complete blood count. The PLR initially served as a systemic inflammatory biomarker to predict the prognosis of neoplastic diseases. In recent years, the PLR has been used as a prognostic marker in cardiovascular (CV) conditions. In this review, we consider the evidence regarding the association of the PLR with CV disease (CVD) and its possible use as a prognostic marker of CVD. The role of PLR has been investigated in CV conditions in several studies. We assessed clinical trials using PubMed, EMBASE, and Web of Science (up to April 18, 2018) to evaluate the association between PLR and mortality/major adverse cardiac events in these conditions. Most of these studies reported significant relationships between a high PLR and diverse outcomes. In conclusion, we suggest that PLR is a cheap and easily available systemic inflammatory marker that can predict distinct outcomes in different types of CVD.

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          Most cited references 138

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          2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

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            2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR).

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              Heart Disease and Stroke Statistics—2016 Update

              Circulation, 133(4)
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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Angiology
                Angiology
                SAGE Publications
                0003-3197
                1940-1574
                June 05 2019
                October 2019
                April 28 2019
                October 2019
                : 70
                : 9
                : 802-818
                Affiliations
                [1 ]Cardiology Department, Tayfur Ata Sokmen Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Antakya, Turkey
                [2 ]Cardiology Department, Ankara Numune Education and Research Hospital, Health Sciences University, Ankara, Turkey
                Article
                10.1177/0003319719845186
                01f2bb1a-e6a8-40ba-a234-895275429d0f
                © 2019

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