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      Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.

      Nature

      genetics, Transcription Factor Pit-1, Signal Transduction, Sequence Homology, Amino Acid, Point Mutation, physiology, embryology, abnormalities, Pituitary Gland, Anterior, Molecular Sequence Data, Mice, Inbred C57BL, Mice, Male, Hypothalamus, Homeodomain Proteins, Gene Expression, Female, Dwarfism, Pituitary, DNA-Binding Proteins, Cell Lineage, Animals, Amino Acid Sequence, Alleles, Transcription Factors

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          Abstract

          The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.

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          Journal
          10.1038/384327a0
          8934515

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