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      Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke.

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          Abstract

          Stroke is the second to third leading cause of death. Toll-like receptor 4 (TLR4) is a signaling receptor in innate immunity that is a specific immunologic response to systemic bacterial infection and cerebral injury. The role of TLR4 in brain ischemia has not been examined yet. We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway.

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          Author and article information

          Journal
          Circulation
          Circulation
          Ovid Technologies (Wolters Kluwer Health)
          1524-4539
          0009-7322
          Mar 27 2007
          : 115
          : 12
          Affiliations
          [1 ] Departamento de Farmacología, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain.
          Article
          CIRCULATIONAHA.106.603431
          10.1161/CIRCULATIONAHA.106.603431
          17372179
          02066382-e754-4ca7-9410-028b9ea4c3d0
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