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      The tail of integrins, talin, and kindlins.

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          Abstract

          Integrins are transmembrane cell-adhesion molecules that carry signals from the outside to the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in response to ligand binding; however, events within the cell can also regulate the affinity of integrins for ligands. This feature is important in physiological situations such as those in blood, in which cells are always in close proximity to their ligands, yet cell-ligand interactions occur only after integrin activation in response to specific external cues. This review focuses on the mechanisms whereby two key proteins, talin and the kindlins, regulate integrin activation by binding the tails of integrin-beta subunits.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          May 15 2009
          : 324
          : 5929
          Affiliations
          [1 ] Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
          Article
          324/5929/895
          10.1126/science.1163865
          19443776
          021084d9-a392-4c69-87f1-348de7707f64
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