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Setbacks in Blood Substitutes Research and Development: A Biochemical Perspective
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Abstract
Recent setbacks in using Hb-based technology to develop oxygen carriers or blood substitutes
may spur new and fundamentally different approaches for the development of a new generation
of hemoglobin-based oxygen carriers (HBOCs). This article briefly details some underlying
mechanisms that may have been responsible for the adverse-event profile associated
with HBOCs, with a focus on the contribution of the author's laboratory toward identifying
some of these biochemical pathways and some ways and means to control them. It is
hoped that this will aid in the development of a safe and effective second generation
of HBOCs.
Published by Elsevier Inc.