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Abstract
Background
Currently, standard segmented cardiac cine and delayed enhancement images are acquired
with independent sequences requiring multiple breath-holds (BH), ideal inversion time
(TI) setting, and individual image analysis. We describe our initial experience with
the use of a multi-contrast real-time cine (multi-TI cine) prototype sequence [1].
Methods
All patients were submitted to a conventional cardiac magnetic resonance study (Magnetom
Aera, Siemens AG Healthcare, Germany) that included short- and long-axis steady-state
free-precession (SSFP) segmented cine measurements (spatial resol.: 1.5x1.5 mm2; slice
thickness: 7 mm; temporal resol.: 40 ms; 7 heart beats (HB)/slice), modified Look-Locker
inversion recovery post-contrast T1 mapping (spatial resol.: 1.6x1.6 mm2; slice thickness:
8 mm; 17 HB/slice), and segmented spoiled gradient-echo late gadolinium enhancement
(LGE) images (spatial resol.: 1.6x1.6 mm2; slice thickness: 8 mm; 8-10 HB/slice).
Followed by multi-TI real-time cine performed in the same cardiac planes (spatial
resol.: 2.1x2.1 mm2; slice thickness: 8 mm; temporal resol.: 45 ms; 4 HB/slice). The
multi-TI cine prototype has been described in detail elsewhere1, but briefly it consists
of an inversion recovery highly accelerated SSFP 2D real-time cine sequence, featuring
sparse sampling and k-t regularization. Using an offline reconstruction algorithm
based on a registration and motion-propagation strategy, a full-length cine can be
reconstructed for each acquired TI (fig. 1) and also a pseudo-T1 map cine.
Figure 1
Offline reconstruction produces up to 26 full cardiac-cycle cines with varying TI.
Three-chamber view on diastole (a, b, c) and systole (e, f, g), with progressively
increasing TI. This patient had a diagnosis of myocarditis and exhibited infero-lateral
mesocardial LGE (arrowheads) on conventional IR-GRE phase (d) and magnitude (h) images,
with preserved contractility on standard SSFP cines (not shown). The mesocardial LGE
and preserved contraction could be simultaneously observed on multi-TI cine (b, f).
Results
A total of 12 consecutive patients (61% male, 50±19 yrs) were included. All sequences
were successfully performed and reconstructed, rendering good-quality images on subjective
analysis. In all patients, a multi-TI cine, with ideal myocardial nulling, could be
produced for simultaneous cardiac function and LGE analysis. Figure 2 illustrates
a case of myocardial infarction with evident apical fibrosis on LGE and post-contrast
T1 map, associated with akinesia of the involved segments on standard cines. On multi-TI
cine, both abnormalities could be fully appreciated. In a subject with myocarditis,
subtle mesocardial LGE without segmental contractility dysfunction was also adequately
depicted on multi-TI cines (fig. 1). Conventional cine and LGE together required more
time and breath-holds than multi-TI cines (745±210 seconds and 13±1 BH vs. 357±39
seconds and 3±0 BH respectively).
Figure 2
Patient with a history of myocardial infarction exhibiting apical fibrosis (arrowheads)
seen with conventional segmented IR-GRE (g) and post-contrast T1 map (h) images. On
standard segmented SSFP cine in diastole (e) and systole (f) there is akinesia of
the infarcted anterior segments. The same pattern of LGE and regional akinesia can
be observed simultaneously on the multi-TI cines in diastole (a and c), systole (b)
and diastolic pseudo-T1 map (d).
Conclusions
Despite currently having inferior spatial and temporal resolution as compared to standard
cine and LGE sequences, multi-TI cine seems to be able to detect myocardial tissue
and functional abnormalities, with the advantage of shorter acquisition times, ideal
myocardial nulling and combined functional and LGE assessment. Future developments
and studies will be needed to adequately determine its accuracy and validate its clinical
application.
Funding
Internal.
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