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      Renal Lesions in Heroin Addicts

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          Abstract

          Percutaneous biopsies were performed in 14 unselected addicts, ranging in age from 21 to 52 years, who had no manifest cardiac, hepatic or sickle-cell disorder. Urinary findings ranged from normal to a trace of protein with a few red blood cells and a few white blood cells; Australian antigen was negative. All were normotensive and blood chemistries were within normal range. By light microscopy, 12 cases exhibited slight nonspecific increase in mesangium. Three cases had, on immunofluorescent studies, mesangial deposits -predominantly of IGm – and two cases had basement membrane deposits of IGg. Electron microscopy revealed focal foot process fusion, increase in mesangium and small electron-dense deposits in six cases. In view of the propensity of addicts to develop variegated renal disorders, the asymptomatic renal lesions herein described may represent early manifestation of kidney disease as a consequence of drug usage and deserve further investigation.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1972
          1972
          27 November 2008
          : 9
          : 6
          : 356-363
          Affiliations
          New York Medical College, Metropolitan and Knickerbocker Hospitals, and Mt. Sinai School of Medicine, City University of New York, New York, N.Y.
          Article
          180169 Nephron 1972;9:356–363
          10.1159/000180169
          4570165
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
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