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      Effects of the Addition of 10 % Glucose to a Normal Saline Infusion in Normal and Hypertensive Subjects

      , , ,

      Nephron

      S. Karger AG

      Hypertension, Natriuresis, Glucose

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          Abstract

          Urinary sodium excretion was studied in normotensive and hypertensive subjects during prolonged infusion with normal saline before and after addition of 10% glucose. The addition of glucose did not cause additional expansion of the extracellular fluid compartment. The increased fractional sodium excretion caused by infusion of normal saline was greater in hypertensives than in normotensives and increased after the addition of glucose to a similar degree in both groups. This finding suggests that the ‘exaggerated natriuresis’ found in hypertensives is not due to an intrinsic alteration in the handling of sodium by the kidney but, rather, to an extrarenal mechanism.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1973
          1973
          28 November 2008
          : 11
          : 6
          : 373-378
          Affiliations
          Laboratory of Clinical Research, Nephrological Service, and the Metabolic Unit, Department of Medicine A, Hadassah University Hospital, Jerusalem
          Article
          180247 Nephron 1973;11:373–378
          10.1159/000180247
          4751519
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

          Natriuresis, Hypertension, Glucose

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