Contributors
Wenxin Song: Role: Data curationRole: InvestigationRole: MethodologyRole: Project administrationRole:
ResourcesRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Qi Luo: Role: Data curationRole: InvestigationRole: MethodologyRole: Project administrationRole:
ResourcesRole: SoftwareRole: ValidationRole: Writing – original draftRole: Writing
– review & editing
Yuping Zhang: Role: Data curationRole: Investigation
Linkang Zhou: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Ye Liu: Role: Investigation
Zhilong Ma: Role: InvestigationRole: MethodologyRole: Visualization
Jianan Guo: Role: Investigation
Yuedong Huang: Role: Investigation
Lili Cheng: Role: Investigation
Ziyi Meng: Role: Investigation
Zicheng Li: Role: Investigation
Bin Zhang: Role: Investigation
Siqi Li: Role: InvestigationRole: Methodology
Sook Wah Yee: Role: Data curationRole: InvestigationRole: MethodologyRole: SoftwareRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Hao Fan: Role: Data curationRole: InvestigationRole: MethodologyRole: Software
Peng Li: Role: InvestigationRole: MethodologyRole: Supervision
Kathleen M. Giacomini: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
ResourcesRole: SupervisionRole: Writing – review & editing
Ligong Chen:
ORCID: http://orcid.org/0000-0002-7893-7173
Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: Writing – original draftRole:
Writing – review & editing
Gokhan Hotamisligil: Role: Academic Editor
Journal
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Journal ID (pmc): plosbiol
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
17
January
2019
Publication date Collection:
January
2019
Publication date PMC-release: 17
January
2019
Volume: 17
Issue: 1
Electronic Location Identifier: e2006571
Affiliations
[1
]
School of Pharmaceutical Sciences, Tsinghua University, Beijing, China
[2
]
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine,
University of California, San Francisco, California
[3
]
Institute for Human Genetics, University of California, San Francisco, California
[4
]
State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences,
School of Life Sciences, Tsinghua University, Beijing, China
[5
]
Institute of Immunology, School of Medicine, Tsinghua University, Beijing, China
[6
]
Bioinformatics Institute, Agency for Science, Technology and Research, Singapore;
Department of Biological Sciences, National University of Singapore, Singapore; Centre
for Computational Biology, DUKE-NUS Medical School, Singapore
[7
]
Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy
and Cancer Center, West China Hospital, West China Medical School, Sichuan University,
Chengdu, China
Harvard School of Public Health, United States of America
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
pbio.2006571
DOI: 10.1371/journal.pbio.2006571
PMC ID: 6336244
PubMed ID: 30653498
SO-VID: 027f7ae8-46ac-4bf1-994a-08e238434c3a
Copyright © © 2019 Song et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 7
May
2018
Date
accepted
: 13
December
2018
Page count
Figures: 6,
Tables: 0,
Pages: 28
Funding
National Key R&D Program of China (grant number No. 2018YFA0506903) received by L.C.
The funder had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript. National Science and Technology Major Projects
for Major New Drugs Innovation and Development (grant number No. 2018ZX09711003-004-002)
received by L.C. The funder had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript. Tsinghua University Initiative
Scientific Research Program (grant number No. 20161080086) received by L.C. The funder
had no role in study design, data collection and analysis, decision to publish, or
preparation of the manuscript. National Natural Science Foundation of China (grant
number No. 81470839) received by L.C. The funder had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript. National
Institutes of Health (grant number GM117163) received by K.M.G. The funder had no
role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Adipocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Adipocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Adipocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Adipose Tissue
Subject:
Brown Adipose Tissue
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Adipose Tissue
Subject:
Brown Adipose Tissue
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Reactions
Subject:
Hydrolysis
Subject:
Lipolysis
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Thermogenesis
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Thermogenesis
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Amines
Subject:
Catecholamines
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Amines
Subject:
Catecholamines
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Neurochemistry
Subject:
Neurotransmitters
Subject:
Biogenic Amines
Subject:
Catecholamines
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neurochemistry
Subject:
Neurotransmitters
Subject:
Biogenic Amines
Subject:
Catecholamines
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Catecholamines
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Bioenergetics
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Temperature
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Temperature
Custom metadata