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Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

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      Abstract

      Ethanolic extract of roots of Ficus hispida was investigated in normal and dexamethasone depressed healing conditions, using incision, excision and dead space wound models in albino rats. The root extract of Ficus hispida has shown the maximum breaking strength compared to control group. The rate of epithelialization and wound contraction in excision model was better as compared to control groups. There was significant increase in granulation tissue weight and hydroxyproline content in dead space model compared to control group. The antihealing effect of dexamethasone was also reverted by the administration of ethanolic extract of Ficus hispida in all the wound models .The results indicated that the root extract of Ficus hispida has a significant wound healing activity and also promotes healing in dexamethasone depressed healing conditions.

      Translated abstract

      O extrato etanólico de raízes de Ficus hispida foi ensaiado em ratos albinos normais e em condições de cicatrização deprimida por dexametasona, utilizando modelos de ferida por incisão, excisão e de espaço morto. O extrato da raiz de Ficus hispida mostrou a força máxima de tensão comparativamente ao grupo controle. A velocidade de epitelização e de contração da ferida no modelo de excisão foi melhor do que a dos grupos controles. Houve aumento significativo no peso do tecido de granulação e no conteúdo de hidroxiprolina no modelo de espaço morto comparativamente ao grupo controle. O efeito anticicatrizante da dexametasona foi, também, revertido pela administração do extrato etanólico de Ficus hispida em todos os modelos de feridas. Os resultados indicaram que o extrato de Ficus hispida tem atividade cicatrizante em feridas e, também, promove a cicatrização em condições de depressão de cicatrização pela dexametasona.

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      Indian material medical

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        Effect of Tridax Procumbens Extracts on Wound Healing

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          Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats.

          The ethanolic extracts of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica were evaluated for their wound healing activity in rats. Wound healing activity was studied using excision and incision wound models in rats following topical application. Animals were divided into four groups with six in each group. Ten percent w/v extract of each plant was prepared in saline for topical application. H. indicum possesses better wound healing activity than P. zeylanicum and A. indica. Tensile strength results indicate better activity of H. indicum on remodeling phase of wound healing.
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            Author and article information

            Affiliations
            [1 ] Dr.K.N.Modi Institute of Pharmaceutical Education & Research centre India
            [2 ] Vidyabharti Trust College of Pharmacy India
            Contributors
            Role: ND
            Role: ND
            Role: ND
            Journal
            bjps
            Brazilian Journal of Pharmaceutical Sciences
            Braz. J. Pharm. Sci.
            Universidade de São Paulo, Faculdade de Ciências Farmacêuticas (São Paulo )
            2175-9790
            December 2011
            : 47
            : 4
            : 855-860
            S1984-82502011000400023 10.1590/S1984-82502011000400023

            http://creativecommons.org/licenses/by/4.0/

            Product
            Product Information: SciELO Brazil
            Categories
            PHARMACOLOGY & PHARMACY

            Pharmacology & Pharmaceutical medicine

            Cicatrização, Ficus hispida, Wound healing

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