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      Helicobacter pylori: present status and future prospects in Japan

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          Abstract

          The discovery of Helicobacter pylori has already changed the natural history of peptic ulcer disease, with most patients being cured at their first presentation. Similarly, the incidence of gastric cancer and other diseases related to H. pylori are likely to be greatly reduced in the near future. Isolation of the spiral intragastric bacterium H. pylori totally reversed the false dogma that the stomach was sterile, and it taught us that chronic infectious disease can still exist in modern society. Helicobacter pylori’s unique location, persistence, and evasion of the immune system offer important insights into the pathophysiology of the gut. Also, the fact that it was overlooked for so long encourages us to think “outside the box” when investigating other diseases with obscure etiologies. We should consider such provocative scientific ideas as bridges to the future disease control.

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          Most cited references173

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          Helicobacter pylori infection.

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            Global cancer statistics in the year 2000.

            D Parkin (2001)
            Estimation of the burden of cancer in terms of incidence, mortality, and prevalence is a first step to appreciating appropriate control measures in a global context. The latest results of such an exercise, based on the most recent available international data, show that there were 10 million new cases, 6 million deaths, and 22 million people living with cancer in 2000. The most common cancers in terms of new cases were lung (1.2 million), breast (1.05 million), colorectal (945,000), stomach (876,000), and liver (564,000). The profile varies greatly in different populations, and the evidence suggests that this variation is mainly a consequence of different lifestyle and environmental factors, which should be amenable to preventive interventions. World population growth and ageing imply a progressive increase in the cancer burden--15 million new cases and 10 million new deaths are expected in 2020, even if current rates remain unchanged.
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              Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.

              Biopsy specimens were taken from intact areas of antral mucosa in 100 consecutive consenting patients presenting for gastroscopy. Spiral or curved bacilli were demonstrated in specimens from 58 patients. Bacilli cultured from 11 of these biopsies were gram-negative, flagellate, and microaerophilic and appeared to be a new species related to the genus Campylobacter. The bacteria were present in almost all patients with active chronic gastritis, duodenal ulcer, or gastric ulcer and thus may be an important factor in the aetiology of these diseases.
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                Author and article information

                Journal
                J Gastroenterol
                Journal of Gastroenterology
                Springer-Verlag (Tokyo )
                0944-1174
                1435-5922
                16 February 2007
                January 2007
                : 42
                : 1
                : 1-15
                Affiliations
                [ ]Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
                [ ]Discipline of Microbiology & Immunology, University of Western Australia, M502, 1. 11 L. Block, QEII Medical Centre, Hosp. Avenue, Nedlands, Western Australia 6009 Australia
                Article
                1990
                10.1007/s00535-006-1990-z
                2780612
                17322988
                029180f8-72e7-4d1b-91ef-aa52e1f2bb6b
                © Springer-Verlag Tokyo 2007
                History
                : 03 December 2006
                : 04 December 2006
                Categories
                Review
                Custom metadata
                © Springer-Verlag Tokyo 2007

                Gastroenterology & Hepatology
                h. pylori diagnosis,h. pylori eradication,gastric cancer,gastritis,peptic ulcer

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