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      Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain.

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      Journal: Antimicrobial Agents and Chemotherapy
      Keywords: Amikacin, pharmacology, Aminoglycosides, Anti-Bacterial Agents, Cephalosporins, Clavulanic Acid, Gentamicins, Humans, Imipenem, Integrons, genetics, Molecular Sequence Data, Penicillanic Acid, analogs & derivatives, Piperacillin, Plasmids, Pseudomonas Infections, microbiology, Pseudomonas aeruginosa, drug effects, enzymology, isolation & purification, Spain, Thienamycins, beta-Lactamases

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          Abstract

          Two clonally related Pseudomonas aeruginosa isolates, recovered from two patients admitted to a pediatric intensive care unit, were found to harbor a new OXA-2 variant (Asn148Asp), designated OXA-161. The plasmid location of bla(OXA-161) was demonstrated through electroporation to PAO1, and its codification in a class I integron (together with aacA4) was demonstrated through PCR and sequencing. bla(OXA-2) and bla(OXA-161) were cloned in parallel to demonstrate the extended-spectrum beta-lactamase properties of OXA-161, conferring resistance to ceftazidime and reduced susceptibility to cefepime and aztreonam.

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          PubMed ID:: 19770278
          PMC ID:: 2786339
          DOI:: 10.1128/AAC.00822-09

          ScienceOpen disciplines: Chemistry
          Keywords: Amikacin,pharmacology,Aminoglycosides,Anti-Bacterial Agents,Cephalosporins,Clavulanic Acid,Gentamicins,Humans,Imipenem,Integrons,genetics,Molecular Sequence Data,Penicillanic Acid,analogs & derivatives,Piperacillin,Plasmids,Pseudomonas Infections,microbiology,Pseudomonas aeruginosa,drug effects,enzymology,isolation & purification,Spain,Thienamycins,beta-Lactamases
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          ScienceOpen disciplines: Chemistry
          Keywords: Amikacin, pharmacology, Aminoglycosides, Anti-Bacterial Agents, Cephalosporins, Clavulanic Acid, Gentamicins, Humans, Imipenem, Integrons, genetics, Molecular Sequence Data, Penicillanic Acid, analogs & derivatives, Piperacillin, Plasmids, Pseudomonas Infections, microbiology, Pseudomonas aeruginosa, drug effects, enzymology, isolation & purification, Spain, Thienamycins, beta-Lactamases

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