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      Effect of Substance P and Receptor Antagonists on Secretion of Lingual Lipase and Amylase from Rat von Ebner's Gland

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          Abstract

          Field, R. B., S. J. Chirtel and R. S. Redman. Effect of substance P and receptor antagonists on secretion of lingual lipase and amylase from rat von Ebner's gland. Peptides 18(2) 277–285, 1997.— Substance P (SP, 1 μM) when incubated with minced von Ebner's glands for 15, 30, and 60 min, stimulated secretion of lingual lipase (12.14%±0.90) and amylase (8.30%±0.42). Only 10 μM of the SP receptor antagonist CP-96,345 significantly inhibited SP-evoked secretion. d-Pro 2- d-Phe 7- d-Trp 9-SP (Ia), d-Pro 2- d-Trp 7,9-SP (Ib), d-Arg 1- d-Trp 7,9- d-Leu 11-SP (Ic), or 1 μM CP-96,345 were not effective, suggesting that the SP receptor of von Ebner's gland might be an isoform. Propranolol and timolol, β 1/ β 2-adrenergic receptor antagonists were not effective and the cholinergic receptor antagonist, atropine, was effective in only slightly reducing amylase secretion but not lingual lipase. Differential secretion of the two enzymes was observed for basal and stimulated secretion. Thus, exocytosis may not be the only pathway involved in SP-evoked protein secretion.

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          Most cited references51

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          Constitutive and regulated secretion of proteins.

          Kevin Kelly, Mark T Burgess (1986)
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            A potent nonpeptide antagonist of the substance P (NK1) receptor.

            H B Woody, J Constantine, R K Snider … (1991)
            CP-96,345 [(2S, 3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)- methyl]-1-azabicyclo[2.2.2]octan-3-amine] is a potent nonpeptide antagonist of the substance P (NK1) receptor. CP-96,345 inhibited 3H-labeled substance P binding and was a classical competitive antagonist in the NK1 monoreceptor dog carotid artery preparation. CP-96,345 inhibited substance P-induced salivation in the rat, a classical in vivo bioassay, but did not inhibit NK2, NK3, or numerous other receptors; it is thus a selective NK1 antagonist. This compound may prove to be a powerful tool for investigation of the physiological properties of substance P and exploration of its role in diseases.
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              Interaction of saliva and taste.

              Lisa A Spielman (1990)
              In spite of the coexistence of saliva and taste in the oral cavity, an understanding of their interactions is still incomplete. Saliva has modulating effects on sour, salt, and the monosodium-glutamate-induced savory or umami taste. It has a diminishing effect on sour taste as a result of the buffering by salivary bicarbonate. It probably also contributes to the umami taste with endogenous salivary glutamate levels. Salt taste is detected only when above salivary sodium-chloride concentrations; thus saliva influences salt taste threshold levels. It also provides the ionic environment for taste cells, probably critical in signal transduction. Salivary flow rate and composition are influenced by the type of taste stimuli. In general, sour taste, elicited by citric acid or sour food, induces the highest flow rate and Na+ concentrations, while salt gives rise to high protein and Ca2+ concentrations. Stimulation with the four basic taste modalities (sour, sweet, salty, and bitter), however, does not increase the relative proportion of any of the salivary proteins. This review examines the literature on the interactions of saliva with taste, and the effect of taste on salivary composition. The possible role of the von Ebner's salivary glands and the role of saliva as a chemical cue are also discussed.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Peptides
                Journal ID (iso-abbrev): Peptides
                Title: Peptides
                Publisher: Elsevier Science Inc.
                ISSN (Print): 0196-9781
                ISSN (Electronic): 1873-5169
                Publication date PMC-release: 24 February 1998
                Publication date (Print): 1997
                Publication date (Electronic): 24 February 1998
                Volume: 18
                Issue: 2
                Pages: 277-285
                Affiliations
                [a ]Department of Veterans Affairs Medical Center, Oral Pathology Research Laboratory, Washington, DC 20422USA
                [b ]Georgetown University Medical Center, Department of Pediatrics, Washington, DC 20007USA
                [c ]Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Mathematics, Washington, DC 20204USA
                Author notes
                [* ]Dr. Ruth B. Field, Department of Veterans Affairs Medical Center, Oral Pathology Research Laboratory (151-I), 50 Irving Street, NW, Washington, DC 20422.
                Article
                Publisher ID: S0196-9781(96)00286-0
                DOI: 10.1016/S0196-9781(96)00286-0
                PMC ID: 7124305
                PubMed ID: 9149301
                SO-VID: 029c0192-e552-438b-8bd4-389b5b5974c5
                Copyright © Copyright © 1997 Elsevier Science Inc. All rights reserved.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Date received : 15 March 1995
                Date accepted : 18 October 1996
                Categories
                Subject: Article

                ScienceOpen disciplines: Biochemistry
                Keywords: substance p,substance p receptors,von ebner's glands,lingual lipase,amylase,protein secretion,substance p analogs,substance p receptor antagonists,β-adrenergic receptor antagonists,cholinergic receptor antagonist,cp-96,345,exocytosis,basal secretion,stimulated secretion
                Data availability:
                ScienceOpen disciplines: Biochemistry
                Keywords: substance p, substance p receptors, von ebner's glands, lingual lipase, amylase, protein secretion, substance p analogs, substance p receptor antagonists, β-adrenergic receptor antagonists, cholinergic receptor antagonist, cp-96,345, exocytosis, basal secretion, stimulated secretion

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