- Record: found
- Abstract: not found
- Article: not found
Receptor clustering and signal processing in E. coli chemotaxis
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Chemotaxis in Escherichia coli is one of the most thoroughly studied model systems
for signal transduction. Receptor-kinase complexes, organized in clusters at the cell
poles, sense chemoeffector stimuli and transmit signals to flagellar motors by phosphorylation
of a diffusible response regulator protein. Despite the apparent simplicity of the
signal transduction pathway, the high sensitivity, wide dynamic range and integration
of multiple stimuli of this pathway remain unexplained. Recent advances in computer
modeling and in quantitative experimental analysis suggest that cooperative protein
interactions in receptor clusters play a crucial role in the signal processing during
bacterial chemotaxis.