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      Cachectin and tumour necrosis factor as two sides of the same biological coin.

      Nature
      Amino Acid Sequence, Animals, Antineoplastic Agents, Biological Evolution, Cachexia, physiopathology, Endotoxins, pharmacology, Genes, Glycoproteins, physiology, therapeutic use, Humans, Lipoprotein Lipase, antagonists & inhibitors, Lymphotoxin-alpha, genetics, Proteins, Receptors, Cell Surface, Receptors, Tumor Necrosis Factor, Sequence Homology, Nucleic Acid, Tumor Necrosis Factor-alpha

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          Abstract

          In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

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