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      Antifouling steroids from the South China Sea gorgonian coral Subergorgia suberosa.

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          Abstract

          Two new unusual cholestane derivatives, pentacyclic steroid 16,22-epoxy-20β,23S-dihydroxycholest-1-ene-3-one (1) and 20β,23S-dihydroxycholest-1-ene-3,22-dione (2), along with two new pregnane derivatives, 15β,17α-dihydroxypregna-4,6-diene-3,20-dione (3) and 11α-hydroxypregna-4-ene-3,6,20-trione (4), were isolated from the South China Sea gorgonian coral Subergorgia suberosa. Their structures were established based on the extensive analyses of 2D NMR, IR, and HRMS. Antifouling tests against Balanus amphitrite larvae settlement indicated that 1 and 2 exhibited inhibitory effect with EC50 values of 5.3, and 14.5 μg/mL, respectively.

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          Author and article information

          Journal
          Steroids
          Steroids
          Elsevier BV
          1878-5867
          0039-128X
          Jan 2014
          : 79
          Affiliations
          [1 ] College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
          [2 ] Division of Life Science, School of Science, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, PR China.
          [3 ] Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
          [4 ] Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
          [5 ] College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Department of Chemistry, Jinan University, Guangzhou 510632, PR China. Electronic address: txush@jnu.edu.cn.
          Article
          S0039-128X(13)00231-6
          10.1016/j.steroids.2013.10.007
          24184487
          02a819c9-3168-43ff-b6db-9820c9a76cd0
          History

          20β,23S-Dihydroxycholest,Antifouing,Gorgonian coral,Pentacyclic steroid,Subergorgia suberosa

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